Guest Research Spotlight: Dr. Roddy O’Connor of the University of Pennsylvania

August 2, 2018 Application Notes, Scientific Blog

In this research spotlight, we feature Dr. Roddy O’Connor at the University of Pennsylvania. Dr. O’Connor works closely with CAR-T luminaries such as Carl June, and now leads his own T cell therapy research team.

As CAR-T cell therapies clear the clinic and become commercially available, advances are needed to safely and effectively improve production methods. Numerous studies have shown that the clinical efficacy of T cell therapy is tied to the maturation stage of the infused cells. Naïve and central memory T cells (see figure below) have superior expansion capability, greater in vivo persistence and reduced exhaustion leading to enhanced therapeutic performance.

Even a small increase in the activity of an infusion could save many lives. In this application note, Dr. O’Connor describes an exciting new method for preserving clinically beneficial T cell phenotypes. Download your free copy to learn his methods and findings!

T cell phenotype

Short on time?
Watch these two summary webinars showcasing Dr. O’Connor’s work:

T cell phenotype webinar
T cell transduction efficiency webinar


Download the full application note

About the Author

Dr. Roddy O’Connor is a Senior Research Investigator at the University of Pennsylvania. His lab studies T cell metabolism and clinical applications for T cell therapy.

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