As CAR-T cell therapies clear the clinic and become commercially available, advances are needed to safely and effectively improve production methods. Numerous studies have shown that the clinical efficacy of T cell therapy is tied to the maturation stage of the infused cells. Naïve and central memory T cells (see figure below) have superior expansion capability, greater in vivo persistence and reduced exhaustion leading to enhanced therapeutic performance.
Even a small increase in the activity of an infusion could save many lives. In this application note, Dr. O’Connor describes an exciting new method for preserving clinically beneficial T cell phenotypes. Download your free copy to learn his methods and findings!
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Watch these two summary webinars showcasing Dr. O’Connor’s work:
Download the full application note
About the Author
Dr. Roddy O’Connor is a Senior Research Investigator at the University of Pennsylvania. His lab studies T cell metabolism and clinical applications for T cell therapy.
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