About This Video
An optimized media can improve the therapeutic potential and in vivo efficacy of a CAR-T cell therapy. Watch this video to see data gathered by Dr. Roddy O’Connor of the University of Pennsylvania on fuel strategies and conditioning methods to boost CAR-T cell transduction, bioactivity, and efficacy. This data is primarily centered on ex-vivo expansion of CAR-T cells for adoptive immunotherapy. In this video, you will learn:
- The concepts of adoptive immunotherapy
- The differences between design and functionality of first and second generation CARs
- The role of glucose consumption in T cell expansion/differentiation
- The rationale for studying media conditions and their effect on CAR-T activity/efficacy
Our speaker
Roddy O'Connor, B.Sc.
Research Assistant Professor
Dr. Roddy O'Connor is a Research Assistant Professor at the Perelman School of Medicine, University of Pennsylvania and, also serves as the Scientific Advisor for Nucleus Biologics. He is a highly regarded expert in CAR-T cell metabolism. His research emphasizes novel conditioning strategies and genetic approaches to confer unique metabolic attributes to CAR T cells. Dr. O’Connor earned his Ph.D. in Molecular Pharmacology from Emory University School of Medicine and later did his postdoctoral research in Cancer Biology and T cell immunotherapy at the University of Pennsylvania. Read more